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KMID : 1225720190110050622
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Allergy, Asthma & Immunology Research : AAIR
2019 Volume.11 No. 5 p.622 ~ p.631
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Cough-Related Laryngeal Sensations and Triggers in Adults With Chronic Cough: Symptom Profile and Impact
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Won Ha-Kyeong
Kang Sung-Yoon
Kang Ye-Won
An Jin
Lee Ji-Hyang
Lee Sang-Min
Kwon Jae-Woo
Kim Min-Hye
Jo Eun-Jung
Lee Seung-Eun
Kim Sae-Hoon
Kim Sang-Heon
Chang Yoon-Seok
Kim Sang-Hoon
Lee Byung-Jae
Cho Sang-Heon
Birring Surinder S.
Song Woo-Jung
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Abstract
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Purpose: Recent evidence suggests that cough hypersensitivity may be a common feature of chronic cough in adults. However, the clinical relevance remains unclear. This study evaluated the cough-related symptom profile and the clinical relevance and impact of cough hypersensitivity in adults with chronic cough.
Methods: This cross-sectional multi-center study compared cough-related laryngeal sensations and cough triggers in patients with unexplained chronic cough following investigations and in unselected patients newly referred for chronic cough. A structured questionnaire was used to assess abnormal laryngeal sensations and cough triggers. Patients with unexplained cough were also evaluated using the Leicester Cough Questionnaire (LCQ) and a cough visual analogue scale (VAS), and these scores were assessed for correlations with the number of triggers and laryngeal sensations.
Results: This study recruited 478 patients, including 62 with unexplained chronic cough and 416 with chronic cough. Most participants reported abnormal laryngeal sensations and cough triggers. Laryngeal sensations (4.4 ± 1.5 vs. 3.9 ± 1.9; P = 0.049) and cough triggers (6.9 ± 2.6 vs. 5.0 ± 2.8; P < 0.001) were more frequent in patients with unexplained chronic cough than in those with chronic cough. The number of triggers and laryngeal sensations score significantly correlated with LCQ (r = ?0.51, P < 0.001) and cough VAS score (r = 0.53, P < 0.001) in patients with unexplained chronic cough.
Conclusions: Cough hypersensitivity may be a common feature in adult patients with chronic cough, especially those with unexplained chronic cough. Cough-related health status and cough severity were inversely associated with the number of triggers and laryngeal sensations, suggesting potential relevance of assessing cough hypersensitivity in chronic cough patients.
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KEYWORD
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Cough, hypersensitivity, symptom assessment
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